Assay Detail
Functional
CHEMBL867528
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Inhibition of estrogen receptor in MCF7 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel chromene-derived selective estrogen receptor modulators useful for alleviating hot flushes and vaginal dryness.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.42 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379415 | — | — | 1 | 6.96 |
| CHEMBL426322 | — | — | 1 | 6.82 |
| CHEMBL210648 | — | — | 1 | 6.66 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 6.65 |
| CHEMBL207324 | — | — | 1 | 6.38 |
| CHEMBL207362 | — | — | 1 | 6.29 |
| CHEMBL208085 | — | — | 1 | 6.22 |
| CHEMBL206680 | — | — | 1 | 6.18 |
| CHEMBL381489 | — | — | 1 | 6.17 |
| CHEMBL210699 | — | — | 1 | 5.85 |
| CHEMBL691 | ETHINYL ESTRADIOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379415 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL426322 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL210648 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL207324 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL207362 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL208085 | — | IC50 | = | 599.0 | nM | 6.22 |
| CHEMBL206680 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL381489 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL210699 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL691 | ETHINYL ESTRADIOL | IC50 | - | — | - |