Assay Detail
Binding
CHEMBL867544
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Inhibition of Plasmodium falciparum recombinant FP2A fused with maltose binding protein
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.94 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423112 | — | — | 1 | 5.30 |
| CHEMBL209147 | — | — | 1 | 5.08 |
| CHEMBL378223 | — | — | 1 | 5.06 |
| CHEMBL207117 | — | — | 1 | 5.06 |
| CHEMBL210211 | — | — | 1 | 4.99 |
| CHEMBL377886 | — | — | 1 | 4.95 |
| CHEMBL382121 | — | — | 1 | 4.87 |
| CHEMBL207102 | — | — | 1 | 4.82 |
| CHEMBL378475 | — | — | 1 | 4.79 |
| CHEMBL437308 | — | — | 1 | 4.72 |
| CHEMBL377557 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423112 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL209147 | — | IC50 | = | 8250.0 | nM | 5.08 |
| CHEMBL378223 | — | IC50 | = | 8680.0 | nM | 5.06 |
| CHEMBL207117 | — | IC50 | = | 8790.0 | nM | 5.06 |
| CHEMBL210211 | — | IC50 | = | 10290.0 | nM | 4.99 |
| CHEMBL377886 | — | IC50 | = | 11190.0 | nM | 4.95 |
| CHEMBL382121 | — | IC50 | = | 13510.0 | nM | 4.87 |
| CHEMBL207102 | — | IC50 | = | 15040.0 | nM | 4.82 |
| CHEMBL378475 | — | IC50 | = | 16340.0 | nM | 4.79 |
| CHEMBL437308 | — | IC50 | = | 19150.0 | nM | 4.72 |
| CHEMBL377557 | — | IC50 | = | 21540.0 | nM | 4.67 |