Assay Detail
Binding
CHEMBL867569
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Inhibitory activity against HIV1 protease expressed in Escherichia coli in a fluorometric assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
A new class of HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.46 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197500 | — | — | 1 | 8.62 |
| CHEMBL436755 | — | — | 1 | 8.22 |
| CHEMBL197165 | — | — | 1 | 8.05 |
| CHEMBL438804 | — | — | 1 | 7.77 |
| CHEMBL372806 | — | — | 1 | 7.75 |
| CHEMBL370132 | — | — | 1 | 7.66 |
| CHEMBL370127 | — | — | 1 | 7.64 |
| CHEMBL369929 | — | — | 1 | 7.20 |
| CHEMBL198534 | — | — | 1 | 6.06 |
| CHEMBL198645 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197500 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL436755 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL197165 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL438804 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL372806 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL370132 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL370127 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL369929 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL198534 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL198645 | — | Ki | = | 2200.0 | nM | 5.66 |