Assay Detail
Binding
CHEMBL867620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]echistatin from AlphaV-beta-3 integrin receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study of their conformational and biological behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.90 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380434 | — | — | 1 | 7.99 |
| CHEMBL413574 | — | — | 1 | 7.73 |
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 7.72 |
| CHEMBL383747 | — | — | 1 | 7.70 |
| CHEMBL204309 | — | — | 1 | 7.45 |
| CHEMBL203693 | — | — | 1 | 7.44 |
| CHEMBL411941 | CYCLORGDFV | — | 1 | 6.71 |
| CHEMBL379056 | — | — | 1 | 6.62 |
| CHEMBL203077 | — | — | 1 | 6.54 |
| CHEMBL2371899 | — | — | 1 | 6.48 |
| CHEMBL381590 | — | — | 1 | 6.15 |
| CHEMBL377066 | — | — | 1 | 5.99 |
| CHEMBL381589 | — | — | 1 | 5.14 |
| CHEMBL203930 | — | — | 1 | - |
| CHEMBL409143 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380434 | — | IC50 | = | 10.31 | nM | 7.99 |
| CHEMBL413574 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL429876 | CILENGITIDE | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL383747 | — | IC50 | = | 19.75 | nM | 7.70 |
| CHEMBL204309 | — | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL203693 | — | IC50 | = | 36.3 | nM | 7.44 |
| CHEMBL411941 | CYCLORGDFV | IC50 | = | 195.9 | nM | 6.71 |
| CHEMBL379056 | — | IC50 | = | 237.1 | nM | 6.62 |
| CHEMBL203077 | — | IC50 | = | 285.3 | nM | 6.54 |
| CHEMBL2371899 | — | IC50 | = | 331.8 | nM | 6.48 |
| CHEMBL381590 | — | IC50 | = | 704.4 | nM | 6.15 |
| CHEMBL377066 | — | IC50 | = | 1017.8 | nM | 5.99 |
| CHEMBL381589 | — | IC50 | = | 7237.9 | nM | 5.14 |
| CHEMBL203930 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL409143 | — | IC50 | > | 1000.0 | nM | - |