Assay Detail
Binding
CHEMBL867681
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Inhibition of isolated human calpain1
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel dual inhibitors of calpain and lipid peroxidation with enhanced cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.06 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203568 | — | — | 1 | 8.31 |
| CHEMBL204883 | — | — | 1 | 8.10 |
| CHEMBL439155 | — | — | 1 | 7.60 |
| CHEMBL201990 | — | — | 1 | 7.42 |
| CHEMBL383110 | — | — | 1 | 7.31 |
| CHEMBL206235 | — | — | 1 | 7.26 |
| CHEMBL203570 | — | — | 1 | 7.12 |
| CHEMBL203244 | — | — | 1 | 7.07 |
| CHEMBL204229 | — | — | 1 | 7.05 |
| CHEMBL203632 | — | — | 2 | 6.98 |
| CHEMBL204046 | — | — | 1 | 6.86 |
| CHEMBL412566 | — | — | 1 | 6.82 |
| CHEMBL206453 | — | — | 1 | 6.82 |
| CHEMBL203448 | — | — | 1 | 6.65 |
| CHEMBL206126 | — | — | 1 | 6.45 |
| CHEMBL204398 | — | — | 1 | 6.26 |
| CHEMBL206571 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203568 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL204883 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL439155 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL201990 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL383110 | — | IC50 | = | 48.7 | nM | 7.31 |
| CHEMBL206235 | — | IC50 | = | 55.4 | nM | 7.26 |
| CHEMBL203570 | — | IC50 | = | 75.9 | nM | 7.12 |
| CHEMBL203244 | — | IC50 | = | 85.5 | nM | 7.07 |
| CHEMBL204229 | — | IC50 | = | 88.6 | nM | 7.05 |
| CHEMBL203632 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL203632 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL204046 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL412566 | — | IC50 | = | 150.9 | nM | 6.82 |
| CHEMBL206453 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL203448 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL206126 | — | IC50 | = | 354.1 | nM | 6.45 |
| CHEMBL204398 | — | IC50 | = | 553.2 | nM | 6.26 |
| CHEMBL206571 | — | IC50 | = | 905.0 | nM | 6.04 |