Assay Detail
Functional
CHEMBL867683
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Inhibition of ferrous induced lipid peroxidation in rat brain microsomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Novel dual inhibitors of calpain and lipid peroxidation with enhanced cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.84 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203632 | — | — | 1 | 6.48 |
| CHEMBL206235 | — | — | 1 | 6.01 |
| CHEMBL203244 | — | — | 1 | 5.96 |
| CHEMBL206571 | — | — | 1 | 5.64 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | 2.0 | 1 | 5.49 |
| CHEMBL206453 | — | — | 1 | 5.48 |
| CHEMBL203568 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203632 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL206235 | — | IC50 | = | 966.0 | nM | 6.01 |
| CHEMBL203244 | — | IC50 | = | 1095.0 | nM | 5.96 |
| CHEMBL206571 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL206453 | — | IC50 | = | 3296.0 | nM | 5.48 |
| CHEMBL203568 | — | IC50 | - | — | - |