Assay Detail
Binding
CHEMBL867801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]I309 from human CCR8 expressed in L1.2 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | L1.2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.89 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205993 | — | — | 1 | 8.22 |
| CHEMBL380492 | — | — | 1 | 8.05 |
| CHEMBL209350 | — | — | 1 | 7.96 |
| CHEMBL204419 | — | — | 1 | 7.82 |
| CHEMBL436753 | — | — | 1 | 7.64 |
| CHEMBL381619 | — | — | 1 | 7.57 |
| CHEMBL379834 | — | — | 1 | 7.22 |
| CHEMBL205447 | — | — | 1 | 7.21 |
| CHEMBL205457 | — | — | 1 | 6.60 |
| CHEMBL210322 | — | — | 1 | 6.60 |
| CHEMBL205692 | — | — | 1 | 5.85 |
| CHEMBL205808 | — | — | 1 | 5.58 |
| CHEMBL205304 | — | — | 1 | 5.04 |
| CHEMBL381354 | — | — | 1 | 5.04 |
| CHEMBL377931 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205993 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL380492 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL209350 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL204419 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL436753 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL381619 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL379834 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL205447 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL205457 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL210322 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL205692 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL205808 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL205304 | — | Ki | = | 9100.0 | nM | 5.04 |
| CHEMBL381354 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL377931 | — | Ki | > | 30000.0 | nM | - |