Assay Detail
Functional
CHEMBL867802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of I309-induced chemotaxis in L1.2 cells expressing CCR8
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | L1.2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.84 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205993 | — | — | 1 | 9.00 |
| CHEMBL380492 | — | — | 1 | 8.40 |
| CHEMBL205447 | — | — | 1 | 7.96 |
| CHEMBL381619 | — | — | 1 | 7.66 |
| CHEMBL204419 | — | — | 1 | 7.37 |
| CHEMBL210322 | — | — | 1 | 7.26 |
| CHEMBL209350 | — | — | 1 | 7.25 |
| CHEMBL205808 | — | — | 1 | - |
| CHEMBL205457 | — | — | 1 | - |
| CHEMBL205692 | — | — | 1 | - |
| CHEMBL381354 | — | — | 1 | - |
| CHEMBL205304 | — | — | 1 | - |
| CHEMBL377931 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205993 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL380492 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL205447 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL381619 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL204419 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL210322 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL209350 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL205808 | — | IC50 | - | — | - | |
| CHEMBL205457 | — | IC50 | - | — | - | |
| CHEMBL205692 | — | IC50 | - | — | - | |
| CHEMBL381354 | — | IC50 | - | — | - | |
| CHEMBL205304 | — | IC50 | - | — | - | |
| CHEMBL377931 | — | IC50 | - | — | - |