Assay Detail
Binding
CHEMBL867907
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Inhibition of BODIPY-AG binding to human HSP90
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.70 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339231 | — | — | 1 | 7.47 |
| CHEMBL209356 | — | — | 1 | 7.47 |
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | 7.21 |
| CHEMBL377559 | RETASPIMYCIN HYDROCHLORIDE | 3.0 | 1 | 7.20 |
| CHEMBL211296 | — | — | 1 | 7.18 |
| CHEMBL211295 | — | — | 1 | 7.04 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.92 |
| CHEMBL378936 | — | — | 1 | 6.27 |
| CHEMBL378935 | — | — | 1 | 6.22 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | 4.06 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | - |
| CHEMBL377782 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339231 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL209356 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL383824 | ALVESPIMYCIN | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL377559 | RETASPIMYCIN HYDROCHLORIDE | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL211296 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL211295 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL109480 | TANESPIMYCIN | EC50 | = | 119.0 | nM | 6.92 |
| CHEMBL378936 | — | EC50 | = | 541.0 | nM | 6.27 |
| CHEMBL378935 | — | EC50 | = | 603.0 | nM | 6.22 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | EC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 1500000.0 | nM | - |
| CHEMBL377782 | — | EC50 | > | 10000.0 | nM | - |