Assay Detail
Binding
CHEMBL867941
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS coronavirus 3CL protease
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Replicase polyprotein 1a (CHEMBL3927) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.59 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213054 | — | — | 1 | 7.28 |
| CHEMBL212080 | — | — | 1 | 7.24 |
| CHEMBL213543 | — | — | 1 | 6.18 |
| CHEMBL277716 | — | — | 1 | 5.65 |
| CHEMBL20636 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213054 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL212080 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL213543 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL277716 | — | Ki | = | 2260.0 | nM | 5.65 |
| CHEMBL20636 | — | Ki | > | 10000.0 | nM | - |