Assay Detail
Functional
CHEMBL867946
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Cytotoxicity against MRC5 cells infected with human coronavirus 229E
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.71 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213054 | — | — | 1 | 6.85 |
| CHEMBL212080 | — | — | 1 | 6.06 |
| CHEMBL213543 | — | — | 1 | 5.04 |
| CHEMBL277716 | — | — | 1 | 4.88 |
| CHEMBL20636 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213054 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL212080 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL213543 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL277716 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL20636 | — | IC50 | > | 20000.0 | nM | - |