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Assay Detail

CHEMBL868069

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Functional
Antiviral activity against HIV1 3B in H9 lymphocytes
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type H9
Confidence 1 — Organism
Curated By Expert

Target

H9 (CHEMBL614806)
Type CELL-LINE
Organism Homo sapiens

Publication

Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.
Yu D, Sakurai Y, Chen CH, Chang FR, Huang L, Kashiwada Y, Lee KH.
J Med Chem (2006) 49 : 5462 -5469
PubMed 16942019 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 6.92 8.15
Activity 3 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL215572 1 8.15
CHEMBL404519 BEVIRIMAT 2.0 1 8.15
CHEMBL214175 1 7.81
CHEMBL215571 1 7.77
CHEMBL211684 1 7.10
CHEMBL211369 1 6.50
CHEMBL266607 1 6.17
CHEMBL211376 1 5.58
CHEMBL380308 1 5.03
CHEMBL385858 1 -
CHEMBL437716 1 -
CHEMBL318169 1 -
CHEMBL377754 1 -
CHEMBL215393 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL215572 EC50 = 7.0 nM 8.15
CHEMBL404519 BEVIRIMAT EC50 = 7.0 nM 8.15
CHEMBL214175 EC50 = 15.6 nM 7.81
CHEMBL215571 EC50 = 17.0 nM 7.77
CHEMBL211684 EC50 = 79.0 nM 7.10
CHEMBL211369 EC50 = 320.0 nM 6.50
CHEMBL266607 EC50 = 680.0 nM 6.17
CHEMBL211376 EC50 = 2600.0 nM 5.58
CHEMBL380308 EC50 = 9300.0 nM 5.03
CHEMBL385858 EC50 - -
CHEMBL437716 EC50 - -
CHEMBL318169 Activity - -
CHEMBL377754 Activity - -
CHEMBL215393 Activity - -