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Assay Detail

CHEMBL868078

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against human CMV by luciferase reporter gene assay in HFF cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type HFF
Confidence 1 — Organism
Curated By Expert

Target

HFF (CHEMBL614071)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of a novel series of inhibitors of human cytomegalovirus primase.
Cushing TD, Adrian J, Chen X, DiMaio H, Doughan B, Flygare J, Liang L, Mayorga V, Miao S, Mellon H, Peterson MG, Powers JP, Spector F, Stein C, Wright M, Xu D, Ye Q, Jaen J.
Bioorg Med Chem Lett (2006) 16 : 4879 -4883
PubMed 16814545 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.14 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL385537 1 7.70
CHEMBL385536 1 7.41
CHEMBL438246 1 6.77
CHEMBL214960 1 6.72
CHEMBL385412 1 6.26
CHEMBL385156 1 6.11
CHEMBL213212 1 5.52
CHEMBL380169 1 5.52
CHEMBL379955 1 5.30
CHEMBL384592 1 5.22
CHEMBL213397 1 5.00
CHEMBL384372 1 -
CHEMBL214676 1 -
CHEMBL214586 1 -
CHEMBL379362 1 -
CHEMBL377117 1 -
CHEMBL212348 1 -
CHEMBL216025 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL385537 IC50 = 20.0 nM 7.70
CHEMBL385536 IC50 = 39.0 nM 7.41
CHEMBL438246 IC50 = 170.0 nM 6.77
CHEMBL214960 IC50 = 190.0 nM 6.72
CHEMBL385412 IC50 = 550.0 nM 6.26
CHEMBL385156 IC50 = 770.0 nM 6.11
CHEMBL213212 IC50 = 3000.0 nM 5.52
CHEMBL380169 IC50 = 3000.0 nM 5.52
CHEMBL379955 IC50 = 5000.0 nM 5.30
CHEMBL384592 IC50 = 6000.0 nM 5.22
CHEMBL213397 IC50 = 10000.0 nM 5.00
CHEMBL384372 IC50 > 30000.0 nM -
CHEMBL214676 IC50 > 30000.0 nM -
CHEMBL214586 IC50 > 30000.0 nM -
CHEMBL379362 IC50 > 30000.0 nM -
CHEMBL377117 IC50 > 30000.0 nM -
CHEMBL212348 IC50 > 30000.0 nM -
CHEMBL216025 IC50 > 30000.0 nM -