Assay Detail
Binding
CHEMBL868157
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Inhibition of SARS CoV 3C-like protease
24
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Replicase polyprotein 1a (CHEMBL3927) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 4.97 | 6.92 |
| IC50 | 8 | 4.91 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358279 | — | — | 3 | 6.92 |
| CHEMBL383725 | — | — | 3 | 5.96 |
| CHEMBL348660 | — | — | 3 | 4.90 |
| CHEMBL379727 | — | — | 3 | 4.72 |
| CHEMBL210525 | — | — | 3 | 4.60 |
| CHEMBL118596 | — | — | 3 | 4.30 |
| CHEMBL209287 | — | — | 3 | 4.18 |
| CHEMBL148483 | — | — | 3 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358279 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL358279 | — | Ki | = | 120.23 | nM | 6.92 |
| CHEMBL358279 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL383725 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL383725 | — | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL383725 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL348660 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL348660 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL348660 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL379727 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL379727 | — | Ki | = | 19054.61 | nM | 4.72 |
| CHEMBL379727 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL210525 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL210525 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL210525 | — | Ki | = | 25118.86 | nM | 4.60 |
| CHEMBL118596 | — | Ki | = | 50118.72 | nM | 4.30 |
| CHEMBL118596 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL118596 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL209287 | — | Ki | = | 66069.34 | nM | 4.18 |
| CHEMBL209287 | — | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL209287 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL148483 | — | Ki | = | 71000.0 | nM | 4.15 |
| CHEMBL148483 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL148483 | — | Ki | = | 72443.6 | nM | 4.14 |