Assay Detail
Binding
CHEMBL868169
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT3
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.29 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210601 | — | — | 1 | 7.57 |
| CHEMBL210833 | — | — | 1 | 7.38 |
| CHEMBL209285 | — | — | 1 | 7.28 |
| CHEMBL380184 | — | — | 1 | 6.96 |
| CHEMBL210359 | — | — | 1 | 6.96 |
| CHEMBL208446 | — | — | 1 | 6.92 |
| CHEMBL208800 | — | — | 1 | 6.89 |
| CHEMBL378924 | — | — | 1 | 6.85 |
| CHEMBL210860 | — | — | 1 | 6.85 |
| CHEMBL426687 | — | — | 1 | 6.85 |
| CHEMBL210960 | — | — | 1 | 6.77 |
| CHEMBL379331 | — | — | 1 | 6.60 |
| CHEMBL210308 | — | — | 1 | 6.60 |
| CHEMBL210227 | — | — | 1 | 6.51 |
| CHEMBL210226 | — | — | 1 | 6.51 |
| CHEMBL210266 | — | — | 1 | 6.44 |
| CHEMBL377567 | — | — | 1 | 6.31 |
| CHEMBL207949 | — | — | 1 | 6.27 |
| CHEMBL379087 | — | — | 1 | 6.25 |
| CHEMBL209928 | — | — | 1 | 6.23 |
| CHEMBL210149 | — | — | 1 | 6.20 |
| CHEMBL377335 | — | — | 1 | 6.20 |
| CHEMBL210907 | — | — | 1 | 6.19 |
| CHEMBL210040 | — | — | 1 | 6.00 |
| CHEMBL209204 | — | — | 1 | 5.96 |
| CHEMBL379367 | — | — | 1 | 5.89 |
| CHEMBL207317 | — | — | 1 | 5.77 |
| CHEMBL210945 | — | — | 1 | 5.70 |
| CHEMBL380229 | — | — | 1 | 5.68 |
| CHEMBL210622 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210601 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL210833 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL209285 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL380184 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL210359 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL208446 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL208800 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL378924 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL210860 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL426687 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL210960 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL379331 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL210308 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL210227 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL210226 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL210266 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL377567 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL207949 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL379087 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL209928 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL210149 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL377335 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL210907 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL210040 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL209204 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL379367 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL207317 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL210945 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL380229 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL210622 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL208974 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL209937 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL378651 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL208973 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL209016 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL210250 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL209562 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL378477 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL210832 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL210095 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL208655 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL210329 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL211020 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL441682 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL210249 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL208628 | — | IC50 | > | 100000.0 | nM | - |