Assay Detail
Binding
CHEMBL868170
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Inhibition of chymotrypsin like activity of yeast 20S proteasome
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proteasome Macropain subunit PRE2 (CHEMBL4659) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Development of lipopeptides for inhibiting 20S proteasomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 4.48 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210325 | — | — | 1 | 5.30 |
| CHEMBL100097 | — | — | 1 | 4.75 |
| CHEMBL209568 | — | — | 1 | 4.70 |
| CHEMBL210871 | — | — | 1 | 4.70 |
| CHEMBL208689 | — | — | 1 | 4.70 |
| CHEMBL439509 | — | — | 1 | 4.55 |
| CHEMBL380390 | — | — | 1 | 4.52 |
| CHEMBL209984 | — | — | 1 | 4.52 |
| CHEMBL425955 | — | — | 1 | 4.47 |
| CHEMBL377322 | — | — | 1 | 4.43 |
| CHEMBL279186 | — | — | 1 | 4.41 |
| CHEMBL379309 | — | — | 1 | 4.37 |
| CHEMBL379749 | — | — | 1 | 4.37 |
| CHEMBL378000 | — | — | 1 | 4.14 |
| CHEMBL207660 | — | — | 1 | 4.10 |
| CHEMBL267439 | — | — | 1 | 4.10 |
| CHEMBL207452 | — | — | 1 | 4.09 |
| CHEMBL378865 | — | — | 1 | - |
| CHEMBL425052 | — | — | 1 | - |
| CHEMBL209258 | — | — | 1 | - |
| CHEMBL378045 | — | — | 1 | - |
| CHEMBL426136 | — | — | 1 | - |
| CHEMBL209290 | — | — | 1 | - |
| CHEMBL379316 | — | — | 1 | - |
| CHEMBL277277 | — | — | 1 | - |
| CHEMBL378002 | — | — | 1 | - |
| CHEMBL426505 | — | — | 1 | - |
| CHEMBL210501 | — | — | 1 | - |
| CHEMBL380055 | — | — | 1 | - |
| CHEMBL378655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210325 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL100097 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL209568 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL210871 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL208689 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL439509 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL380390 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL209984 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL425955 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL377322 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL279186 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL379309 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL379749 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL378000 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL207660 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL267439 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL207452 | — | Ki | = | 81000.0 | nM | 4.09 |
| CHEMBL378865 | — | Ki | > | 80000.0 | nM | - |
| CHEMBL425052 | — | Ki | > | 80000.0 | nM | - |
| CHEMBL209258 | — | Ki | > | 80000.0 | nM | - |
| CHEMBL378045 | — | Ki | = | 619000.0 | nM | - |
| CHEMBL426136 | — | Ki | > | 625000.0 | nM | - |
| CHEMBL209290 | — | Ki | > | 80000.0 | nM | - |
| CHEMBL379316 | — | Ki | > | 80000.0 | nM | - |
| CHEMBL277277 | — | Ki | = | 151000.0 | nM | - |
| CHEMBL378002 | — | Ki | > | 625000.0 | nM | - |
| CHEMBL426505 | — | Ki | > | 625000.0 | nM | - |
| CHEMBL210501 | — | Ki | = | 545000.0 | nM | - |
| CHEMBL380055 | — | Ki | > | 625000.0 | nM | - |
| CHEMBL378655 | — | Ki | = | 139000.0 | nM | - |