Assay Detail
Binding
CHEMBL868300
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Inhibition of recombinant human cathepsin B in a fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.95 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203663 | — | — | 1 | 7.75 |
| CHEMBL113948 | — | — | 1 | 7.57 |
| CHEMBL204605 | — | — | 1 | 6.57 |
| CHEMBL114161 | — | — | 1 | 6.34 |
| CHEMBL117658 | — | — | 1 | 6.09 |
| CHEMBL426308 | — | — | 1 | 5.75 |
| CHEMBL96875 | — | — | 1 | 4.50 |
| CHEMBL205173 | — | — | 1 | 4.50 |
| CHEMBL381715 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203663 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL113948 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL204605 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL114161 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL117658 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL426308 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL96875 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL205173 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL381715 | — | IC50 | = | 35000.0 | nM | 4.46 |