Assay Detail
Binding
CHEMBL868375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 7.84 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382242 | — | — | 1 | 9.40 |
| CHEMBL203867 | — | — | 1 | 9.36 |
| CHEMBL206488 | — | — | 1 | 9.24 |
| CHEMBL206253 | NETUPITANT | 4.0 | 1 | 9.02 |
| CHEMBL204694 | BEFETUPITANT | 2.0 | 1 | 9.00 |
| CHEMBL381832 | — | — | 1 | 8.96 |
| CHEMBL380705 | — | — | 1 | 8.89 |
| CHEMBL206171 | — | — | 1 | 8.85 |
| CHEMBL205829 | — | — | 1 | 8.77 |
| CHEMBL383125 | — | — | 1 | 8.77 |
| CHEMBL380510 | — | — | 1 | 8.70 |
| CHEMBL206268 | — | — | 1 | 8.48 |
| CHEMBL381058 | — | — | 1 | 8.47 |
| CHEMBL203605 | — | — | 1 | 8.46 |
| CHEMBL265986 | — | — | 1 | 8.42 |
| CHEMBL203481 | — | — | 1 | 8.40 |
| CHEMBL206294 | — | — | 1 | 8.34 |
| CHEMBL381081 | — | — | 1 | 8.21 |
| CHEMBL204958 | — | — | 1 | 8.07 |
| CHEMBL204327 | — | — | 1 | 7.82 |
| CHEMBL444624 | — | — | 1 | 7.77 |
| CHEMBL382043 | — | — | 1 | 7.66 |
| CHEMBL202720 | — | — | 1 | 7.35 |
| CHEMBL206274 | — | — | 1 | 7.31 |
| CHEMBL203109 | — | — | 1 | 7.29 |
| CHEMBL203928 | — | — | 1 | 7.17 |
| CHEMBL204165 | — | — | 1 | 7.03 |
| CHEMBL425768 | — | — | 1 | 6.76 |
| CHEMBL206490 | — | — | 1 | 6.65 |
| CHEMBL436951 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382242 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL203867 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL206488 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL206253 | NETUPITANT | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL204694 | BEFETUPITANT | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL381832 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL380705 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL206171 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL205829 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL383125 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL380510 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL206268 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL381058 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL203605 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL265986 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL203481 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL206294 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL381081 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL204958 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL204327 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL444624 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL382043 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL202720 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL206274 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL203109 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL203928 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL204165 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL425768 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL206490 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL436951 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL381179 | — | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL380827 | — | Ki | = | 372.0 | nM | 6.43 |
| CHEMBL381744 | — | Ki | = | 562.0 | nM | 6.25 |
| CHEMBL438801 | — | Ki | = | 724.0 | nM | 6.14 |
| CHEMBL383289 | — | Ki | = | 933.0 | nM | 6.03 |
| CHEMBL206016 | — | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL382989 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL202962 | — | Ki | > | 10000.0 | nM | - |