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Assay Detail

CHEMBL868414

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Transactivation by human PPAR gamma in COS1 cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type COS-1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Peroxisome proliferator-activated receptor gamma (CHEMBL235)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of potent and subtype-selective PPARalpha agonists.
Desai RC, Metzger E, Santini C, Meinke PT, Heck JV, Berger JP, MacNaul KL, Cai TQ, Wright SD, Agrawal A, Moller DE, Sahoo SP.
Bioorg Med Chem Lett (2006) 16 : 1673 -1678
PubMed 16384704 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 28 7.10 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL300026 1 7.10
CHEMBL202973 1 -
CHEMBL205725 1 -
CHEMBL206794 1 -
CHEMBL380837 1 -
CHEMBL203940 1 -
CHEMBL377508 1 -
CHEMBL203621 1 -
CHEMBL206759 1 -
CHEMBL202739 1 -
CHEMBL424685 1 -
CHEMBL203409 1 -
CHEMBL203338 1 -
CHEMBL2113219 1 -
CHEMBL206202 1 -
CHEMBL205803 1 -
CHEMBL382178 1 -
CHEMBL205665 1 -
CHEMBL203408 1 -
CHEMBL383011 1 -
CHEMBL203793 1 -
CHEMBL202631 1 -
CHEMBL1783064 1 -
CHEMBL204875 1 -
CHEMBL206285 1 -
CHEMBL205777 1 -
CHEMBL205358 1 -
CHEMBL424674 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL300026 EC50 = 80.0 nM 7.10
CHEMBL202973 EC50 - -
CHEMBL205725 EC50 - -
CHEMBL206794 EC50 - -
CHEMBL380837 EC50 - -
CHEMBL203940 EC50 - -
CHEMBL377508 EC50 - -
CHEMBL203621 EC50 - -
CHEMBL206759 EC50 > 3000.0 nM -
CHEMBL202739 EC50 > 3000.0 nM -
CHEMBL424685 EC50 > 3000.0 nM -
CHEMBL203409 EC50 > 3000.0 nM -
CHEMBL203338 EC50 - -
CHEMBL2113219 EC50 - -
CHEMBL206202 EC50 - -
CHEMBL205803 EC50 - -
CHEMBL382178 EC50 - -
CHEMBL205665 EC50 - -
CHEMBL203408 EC50 - -
CHEMBL383011 EC50 - -
CHEMBL203793 EC50 - -
CHEMBL202631 EC50 - -
CHEMBL1783064 EC50 - -
CHEMBL204875 EC50 - -
CHEMBL206285 EC50 - -
CHEMBL205777 EC50 - -
CHEMBL205358 EC50 - -
CHEMBL424674 EC50 - -