Assay Detail
Functional
CHEMBL868460
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Antiproliferative activity against HeLa cells by MTS assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.28 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206812 | — | — | 1 | 6.08 |
| CHEMBL202635 | — | — | 1 | 5.81 |
| CHEMBL206460 | — | — | 1 | 5.11 |
| CHEMBL381517 | — | — | 1 | 5.06 |
| CHEMBL205449 | — | — | 1 | 4.84 |
| CHEMBL207778 | — | — | 1 | 4.79 |
| CHEMBL207596 | — | — | 1 | - |
| CHEMBL379095 | — | — | 1 | - |
| CHEMBL208332 | — | — | 1 | - |
| CHEMBL206997 | — | — | 1 | - |
| CHEMBL206213 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206812 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL202635 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL206460 | — | EC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL381517 | — | EC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL205449 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL207778 | — | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL207596 | — | EC50 | > | 58900.0 | nM | - |
| CHEMBL379095 | — | EC50 | > | 58900.0 | nM | - |
| CHEMBL208332 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL206997 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL206213 | — | EC50 | > | 59300.0 | nM | - |