Assay Detail
Functional
CHEMBL868461
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Antiproliferative activity against HeLa cells in presence of 100 nM doxorubicin by MTS assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.64 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206812 | — | — | 1 | 6.66 |
| CHEMBL206460 | — | — | 1 | 6.39 |
| CHEMBL208332 | — | — | 1 | 6.36 |
| CHEMBL202635 | — | — | 1 | 6.12 |
| CHEMBL381517 | — | — | 1 | 6.05 |
| CHEMBL205449 | — | — | 1 | 5.33 |
| CHEMBL207778 | — | — | 1 | 5.18 |
| CHEMBL379095 | — | — | 1 | 4.91 |
| CHEMBL207596 | — | — | 1 | 4.82 |
| CHEMBL206213 | — | — | 1 | 4.62 |
| CHEMBL206997 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206812 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL206460 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL208332 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL202635 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL381517 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL205449 | — | EC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL207778 | — | EC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL379095 | — | EC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL207596 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL206213 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL206997 | — | EC50 | > | 59300.0 | nM | - |