Assay Detail
Functional
CHEMBL868537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human MC1R by cAMP accumulation in SaoS2 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SAOS-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL3795) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of cyclic peptides with agonist activity at melanocortin receptor-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.64 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 8.74 |
| CHEMBL379959 | — | — | 1 | 7.17 |
| CHEMBL264120 | — | — | 1 | 7.11 |
| CHEMBL3143817 | — | — | 1 | 6.87 |
| CHEMBL379531 | — | — | 1 | 6.57 |
| CHEMBL379627 | — | — | 1 | 5.88 |
| CHEMBL210399 | — | — | 1 | 5.48 |
| CHEMBL211131 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214332 | INTERMEDINE | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL379959 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL264120 | — | EC50 | = | 77.4 | nM | 7.11 |
| CHEMBL3143817 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL379531 | — | EC50 | = | 269.9 | nM | 6.57 |
| CHEMBL379627 | — | EC50 | = | 1303.7 | nM | 5.88 |
| CHEMBL210399 | — | EC50 | = | 3301.8 | nM | 5.48 |
| CHEMBL211131 | — | EC50 | = | 5095.8 | nM | 5.29 |