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Assay Detail

CHEMBL868540

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Selectivity for human MC4R over MC1R
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Expert

Target

Melanocortin receptor (M1 and M4) (CHEMBL2111423)
Type SELECTIVITY GROUP
Organism Homo sapiens

Publication

Design of cyclic peptides with agonist activity at melanocortin receptor-4.
Odagami T, Tsuda Y, Kogami Y, Kouji H, Okada Y.
Bioorg Med Chem Lett (2006) 16 : 3723 -3726
PubMed 16678415 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 8 9.27 10.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL214332 INTERMEDINE 2.0 1 10.62
CHEMBL379531 1 9.77
CHEMBL210399 1 9.48
CHEMBL379627 1 9.38
CHEMBL211131 1 9.28
CHEMBL3143817 1 8.92
CHEMBL379959 1 8.37
CHEMBL264120 1 8.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL214332 INTERMEDINE EC50 = 0.024 nM 10.62
CHEMBL379531 EC50 = 0.17 nM 9.77
CHEMBL210399 EC50 = 0.33 nM 9.48
CHEMBL379627 EC50 = 0.42 nM 9.38
CHEMBL211131 EC50 = 0.53 nM 9.28
CHEMBL3143817 EC50 = 1.19 nM 8.92
CHEMBL379959 EC50 = 4.3 nM 8.37
CHEMBL264120 EC50 = 4.7 nM 8.33