Assay Detail
Binding
CHEMBL868604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AchE
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.27 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427232 | — | — | 1 | 7.75 |
| CHEMBL209392 | — | — | 1 | 7.15 |
| CHEMBL211520 | — | — | 1 | 6.87 |
| CHEMBL380050 | — | — | 1 | 6.60 |
| CHEMBL209924 | — | — | 1 | 6.15 |
| CHEMBL212162 | — | — | 1 | 5.95 |
| CHEMBL212111 | — | — | 1 | 5.92 |
| CHEMBL209863 | — | — | 1 | 5.67 |
| CHEMBL211471 | NEOSTIGMINE METHYLSULFATE | 4.0 | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427232 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL209392 | — | IC50 | = | 70.5 | nM | 7.15 |
| CHEMBL211520 | — | IC50 | = | 135.2 | nM | 6.87 |
| CHEMBL380050 | — | IC50 | = | 252.9 | nM | 6.60 |
| CHEMBL209924 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL212162 | — | IC50 | = | 1136.2 | nM | 5.95 |
| CHEMBL212111 | — | IC50 | = | 1210.2 | nM | 5.92 |
| CHEMBL209863 | — | IC50 | = | 2127.4 | nM | 5.67 |
| CHEMBL211471 | NEOSTIGMINE METHYLSULFATE | IC50 | = | 41100.0 | nM | 4.39 |