Assay Detail
Binding
CHEMBL868655
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Inhibition of HDAC6
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.43 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379049 | — | — | 1 | 7.64 |
| CHEMBL213934 | — | — | 1 | 7.54 |
| CHEMBL209551 | — | — | 1 | 7.44 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379049 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL213934 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL209551 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 81.0 | nM | 7.09 |