Assay Detail
Functional
CHEMBL868693
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Effect of compound on degradation of collagen in osteoclast bone resorption assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Cell Type | Osteoclast |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.15 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426819 | — | — | 1 | 8.30 |
| CHEMBL199358 | — | — | 1 | 7.39 |
| CHEMBL371064 | BALICATIB | 2.0 | 1 | 7.01 |
| CHEMBL184514 | — | — | 1 | 6.83 |
| CHEMBL200301 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426819 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL199358 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL371064 | BALICATIB | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL184514 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL200301 | — | IC50 | = | 580.0 | nM | 6.24 |