Assay Detail
Binding
CHEMBL868694
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Inhibitory activity against mouse cathepsin S
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.39 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200884 | — | — | 1 | 7.89 |
| CHEMBL200301 | — | — | 1 | 5.35 |
| CHEMBL426819 | — | — | 1 | 5.27 |
| CHEMBL371064 | BALICATIB | 2.0 | 1 | 5.20 |
| CHEMBL199358 | — | — | 1 | 5.07 |
| CHEMBL198848 | — | — | 1 | 4.48 |
| CHEMBL184514 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200884 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL200301 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL426819 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL371064 | BALICATIB | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL199358 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL198848 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL184514 | — | IC50 | = | 34100.0 | nM | 4.47 |