Assay Detail
Binding
CHEMBL869047
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Inhibition of Sprague-Dawley rat brain HO2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.60 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537200 | — | — | 1 | 4.80 |
| CHEMBL70611 | AZALANSTAT | 2.0 | 1 | 4.55 |
| CHEMBL536512 | — | — | 1 | 4.46 |
| CHEMBL541899 | — | — | 1 | - |
| CHEMBL552550 | — | — | 1 | - |
| CHEMBL535614 | — | — | 1 | - |
| CHEMBL535613 | — | — | 1 | - |
| CHEMBL536056 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537200 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL70611 | AZALANSTAT | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL536512 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL541899 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL552550 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL535614 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL535613 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL536056 | — | IC50 | = | 305000.0 | nM | - |