Assay Detail
Binding
CHEMBL869094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to complement C3
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.23 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1791380 | — | — | 1 | 7.82 |
| CHEMBL427239 | — | — | 1 | 7.77 |
| CHEMBL219860 | — | — | 1 | 7.46 |
| CHEMBL434556 | — | — | 1 | 6.96 |
| CHEMBL1791379 | — | — | 1 | 6.92 |
| CHEMBL252927 | — | — | 1 | 6.85 |
| CHEMBL1791382 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1791380 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL427239 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL219860 | — | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL434556 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL1791379 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL252927 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL1791382 | — | Kd | = | 150.0 | nM | 6.82 |