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Assay Detail

CHEMBL869191

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of scrapie prion formation in mouse ScN2a cell line relative to control
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type ScN2a
Confidence 1 — Organism
Curated By Intermediate

Target

ScN2a (CHEMBL613872)
Type CELL-LINE
Organism Mus musculus

Publication

Similar structure-activity relationships of quinoline derivatives for antiprion and antimalarial effects.
Klingenstein R, Melnyk P, Leliveld SR, Ryckebusch A, Korth C.
J Med Chem (2006) 49 : 5300 -5308
PubMed 16913719 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 40 6.52 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL356005 1 7.30
CHEMBL315677 1 7.12
CHEMBL213431 1 7.12
CHEMBL377805 1 7.12
CHEMBL89861 1 7.10
CHEMBL152553 1 7.10
CHEMBL153430 1 7.05
CHEMBL150645 1 7.00
CHEMBL86622 1 7.00
CHEMBL214434 1 7.00
CHEMBL425619 1 7.00
CHEMBL149751 1 7.00
CHEMBL213269 1 7.00
CHEMBL87110 1 6.82
CHEMBL152059 1 6.76
CHEMBL86727 1 6.70
CHEMBL152266 1 6.70
CHEMBL359359 1 6.70
CHEMBL152229 1 6.70
CHEMBL422682 1 6.60
CHEMBL385657 1 6.60
CHEMBL213095 1 6.60
CHEMBL215410 1 6.60
CHEMBL89645 1 6.60
CHEMBL315079 1 6.60
CHEMBL378518 1 6.52
CHEMBL345264 1 6.52
CHEMBL90157 1 6.30
CHEMBL405238 1 6.30
CHEMBL357028 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL356005 EC50 = 50.0 nM 7.30
CHEMBL315677 EC50 = 75.0 nM 7.12
CHEMBL213431 EC50 = 75.0 nM 7.12
CHEMBL377805 EC50 = 75.0 nM 7.12
CHEMBL89861 EC50 = 80.0 nM 7.10
CHEMBL152553 EC50 = 80.0 nM 7.10
CHEMBL153430 EC50 = 90.0 nM 7.05
CHEMBL214434 EC50 = 100.0 nM 7.00
CHEMBL86622 EC50 = 100.0 nM 7.00
CHEMBL425619 EC50 = 100.0 nM 7.00
CHEMBL149751 EC50 = 100.0 nM 7.00
CHEMBL150645 EC50 = 100.0 nM 7.00
CHEMBL213269 EC50 = 100.0 nM 7.00
CHEMBL87110 EC50 = 150.0 nM 6.82
CHEMBL152059 EC50 = 175.0 nM 6.76
CHEMBL86727 EC50 = 200.0 nM 6.70
CHEMBL152229 EC50 = 200.0 nM 6.70
CHEMBL359359 EC50 = 200.0 nM 6.70
CHEMBL152266 EC50 = 200.0 nM 6.70
CHEMBL385657 EC50 = 250.0 nM 6.60
CHEMBL315079 EC50 = 250.0 nM 6.60
CHEMBL89645 EC50 = 250.0 nM 6.60
CHEMBL213095 EC50 = 250.0 nM 6.60
CHEMBL422682 EC50 = 250.0 nM 6.60
CHEMBL215410 EC50 = 250.0 nM 6.60
CHEMBL378518 EC50 = 300.0 nM 6.52
CHEMBL345264 EC50 = 300.0 nM 6.52
CHEMBL90157 EC50 = 500.0 nM 6.30
CHEMBL405238 EC50 = 500.0 nM 6.30
CHEMBL357028 EC50 = 500.0 nM 6.30
CHEMBL384639 EC50 = 600.0 nM 6.22
CHEMBL152052 EC50 = 750.0 nM 6.12
CHEMBL356238 EC50 = 800.0 nM 6.10
CHEMBL264351 EC50 = 1000.0 nM 6.00
CHEMBL46524 EC50 = 3000.0 nM 5.52
CHEMBL215463 EC50 = 3000.0 nM 5.52
CHEMBL298436 EC50 = 3000.0 nM 5.52
CHEMBL76 CHLOROQUINE EC50 = 4000.0 nM 5.40
CHEMBL407484 EC50 = 5000.0 nM 5.30
CHEMBL86583 EC50 = 6000.0 nM 5.22