Assay Detail
Functional
CHEMBL869286
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Inhibition of IL4-induced IgE synthesis in human peripheral blood lymphocytes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBL |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Small molecule inhibitors of IgE synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.35 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213625 | — | — | 1 | 7.75 |
| CHEMBL212340 | — | — | 1 | 7.43 |
| CHEMBL214145 | — | — | 1 | 7.41 |
| CHEMBL385142 | — | — | 1 | 7.31 |
| CHEMBL214199 | — | — | 1 | 7.26 |
| CHEMBL212980 | — | — | 1 | 6.93 |
| CHEMBL215604 | — | — | 1 | - |
| CHEMBL210206 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213625 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL212340 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL214145 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL385142 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL214199 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL212980 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL215604 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL210206 | — | IC50 | > | 10000.0 | nM | - |