Assay Detail
Binding
CHEMBL869293
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Inhibition of CDK2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.12 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191003 | JNJ-7706621 | — | 1 | 8.70 |
| CHEMBL379193 | — | — | 1 | 7.21 |
| CHEMBL209280 | — | — | 1 | 7.15 |
| CHEMBL378420 | — | — | 1 | 6.93 |
| CHEMBL378248 | — | — | 1 | 6.92 |
| CHEMBL212264 | — | — | 1 | 6.85 |
| CHEMBL210581 | — | — | 1 | 6.61 |
| CHEMBL210765 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL379193 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL209280 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL378420 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL378248 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL212264 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL210581 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL210765 | — | IC50 | = | 266.0 | nM | 6.58 |