Assay Detail
Binding
CHEMBL869402
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Inhibition of recombinant human cytosolic isozyme CA II
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.12 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24259 | PHENYLSULFAMATE | — | 1 | 8.89 |
| CHEMBL122708 | EMATE | — | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL11185 | — | — | 1 | 7.60 |
| CHEMBL198913 | — | — | 1 | 7.50 |
| CHEMBL1628081 | — | — | 1 | 7.10 |
| CHEMBL370854 | — | — | 1 | 7.01 |
| CHEMBL198891 | — | — | 1 | 6.98 |
| CHEMBL370159 | — | — | 1 | 6.95 |
| CHEMBL199493 | — | — | 1 | 6.95 |
| CHEMBL371870 | PHENYLDIFLUOROMETHANESULFONAMIDE | — | 1 | 6.81 |
| CHEMBL199464 | — | — | 1 | 6.46 |
| CHEMBL200673 | — | — | 1 | 6.25 |
| CHEMBL369953 | PHENYLMETHANESULFONAMIDE | — | 1 | 6.19 |
| CHEMBL1628004 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24259 | PHENYLSULFAMATE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL122708 | EMATE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL11185 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL198913 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL1628081 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL370854 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL198891 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL370159 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL199493 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL371870 | PHENYLDIFLUOROMETHANESULFONAMIDE | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL199464 | — | Ki | = | 348.0 | nM | 6.46 |
| CHEMBL200673 | — | Ki | = | 565.0 | nM | 6.25 |
| CHEMBL369953 | PHENYLMETHANESULFONAMIDE | Ki | = | 645.0 | nM | 6.19 |
| CHEMBL1628004 | — | Ki | = | 670.0 | nM | 6.17 |