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Assay Detail

CHEMBL869549

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Binding
Inhibitory activity against SGLT1 expressed in CHO-K1 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Sodium/glucose cotransporter 1 (CHEMBL4979)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2.
Zhang X, Urbanski M, Patel M, Cox GG, Zeck RE, Bian H, Conway BR, Beavers MP, Rybczynski PJ, Demarest KT.
Bioorg Med Chem Lett (2006) 16 : 1696 -1701
PubMed 16380256 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.88 6.86

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL183937 1 6.86
CHEMBL200438 1 6.84
CHEMBL200394 1 6.21
CHEMBL381923 1 5.96
CHEMBL381695 1 5.92
CHEMBL208885 1 5.82
CHEMBL206513 1 5.71
CHEMBL382340 1 5.67
CHEMBL383266 1 5.65
CHEMBL540968 1 5.54
CHEMBL202842 1 5.50
CHEMBL206724 1 5.44
CHEMBL203953 1 5.36
CHEMBL377301 1 -
CHEMBL206395 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL183937 IC50 = 139.0 nM 6.86
CHEMBL200438 IC50 = 145.0 nM 6.84
CHEMBL200394 IC50 = 611.0 nM 6.21
CHEMBL381923 IC50 = 1100.0 nM 5.96
CHEMBL381695 IC50 = 1190.0 nM 5.92
CHEMBL208885 IC50 = 1510.0 nM 5.82
CHEMBL206513 IC50 = 1970.0 nM 5.71
CHEMBL382340 IC50 = 2140.0 nM 5.67
CHEMBL383266 IC50 = 2240.0 nM 5.65
CHEMBL540968 IC50 = 2890.0 nM 5.54
CHEMBL202842 IC50 = 3200.0 nM 5.50
CHEMBL206724 IC50 = 3610.0 nM 5.44
CHEMBL203953 IC50 = 4390.0 nM 5.36
CHEMBL377301 IC50 - -
CHEMBL206395 IC50 - -