Assay Detail
Binding
CHEMBL869601
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Binding affinity to MCT1 by SPA
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.48 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205526 | — | — | 1 | 10.10 |
| CHEMBL205807 | — | — | 1 | 9.10 |
| CHEMBL208487 | — | — | 1 | 8.72 |
| CHEMBL207100 | — | — | 1 | 8.41 |
| CHEMBL205092 | — | — | 1 | 8.33 |
| CHEMBL205742 | — | — | 1 | 8.32 |
| CHEMBL204476 | — | — | 1 | 8.28 |
| CHEMBL426851 | — | — | 1 | 8.18 |
| CHEMBL204772 | — | — | 1 | 7.80 |
| CHEMBL205245 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205526 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL205807 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL208487 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL207100 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL205092 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL205742 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL204476 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL426851 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL204772 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL205245 | — | Ki | = | 26.0 | nM | 7.58 |