Assay Detail
Binding
CHEMBL869625
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human EP3 receptor expressed in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL3710) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.70 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382197 | — | — | 1 | 4.70 |
| CHEMBL203780 | — | — | 1 | - |
| CHEMBL206774 | — | — | 1 | - |
| CHEMBL205819 | — | — | 1 | - |
| CHEMBL383515 | — | — | 1 | - |
| CHEMBL425243 | — | — | 1 | - |
| CHEMBL444798 | — | — | 1 | - |
| CHEMBL427035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382197 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL203780 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL206774 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL205819 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL383515 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL425243 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL444798 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL427035 | — | IC50 | > | 3200.0 | nM | - |