Assay Detail
Functional
CHEMBL869752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human recombinant CXCR4 expressed in CHO cells assessed as inhibition of human SDF1-alpha-stimulated calcium mobilization
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.17 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536288 | — | — | 1 | 5.17 |
| CHEMBL556188 | — | — | 1 | - |
| CHEMBL540108 | — | — | 1 | - |
| CHEMBL556798 | — | — | 1 | - |
| CHEMBL540366 | — | — | 1 | - |
| CHEMBL536743 | — | — | 1 | - |
| CHEMBL537424 | — | — | 1 | - |
| CHEMBL557015 | — | — | 1 | - |
| CHEMBL538084 | — | — | 1 | - |
| CHEMBL537425 | — | — | 1 | - |
| CHEMBL557199 | — | — | 1 | - |
| CHEMBL557150 | — | — | 1 | - |
| CHEMBL535616 | — | — | 1 | - |
| CHEMBL536063 | — | — | 1 | - |
| CHEMBL539854 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536288 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL556188 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL540108 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL556798 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL540366 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL536743 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL537424 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL557015 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL538084 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL537425 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL557199 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL557150 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL535616 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL536063 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL539854 | — | IC50 | > | 30000.0 | nM | - |