Assay Detail
Binding
CHEMBL869770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of strand transfer activity of HIV integrase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.54 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209854 | — | — | 1 | 7.44 |
| CHEMBL414850 | — | — | 1 | 7.30 |
| CHEMBL209440 | — | — | 1 | 7.30 |
| CHEMBL211634 | — | — | 1 | 7.16 |
| CHEMBL212921 | — | — | 1 | 7.10 |
| CHEMBL211110 | — | — | 1 | 6.72 |
| CHEMBL379382 | — | — | 1 | 6.47 |
| CHEMBL378395 | — | — | 1 | 6.46 |
| CHEMBL210396 | — | — | 1 | 6.12 |
| CHEMBL377693 | — | — | 1 | 5.92 |
| CHEMBL209591 | — | — | 1 | 5.70 |
| CHEMBL211275 | — | — | 1 | 5.68 |
| CHEMBL212320 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209854 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL414850 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL209440 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL211634 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL212921 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL211110 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL379382 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL378395 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL210396 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL377693 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL209591 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL211275 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL212320 | — | IC50 | = | 2400.0 | nM | 5.62 |