Assay Detail
Binding
CHEMBL869776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of strand transfer activity in HIV1 integrase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.74 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212213 | — | — | 1 | 8.14 |
| CHEMBL212982 | — | — | 1 | 7.48 |
| CHEMBL209440 | — | — | 1 | 7.30 |
| CHEMBL386055 | — | — | 1 | 7.03 |
| CHEMBL209488 | — | — | 1 | 6.68 |
| CHEMBL214371 | — | — | 1 | 6.59 |
| CHEMBL380034 | — | — | 1 | 6.07 |
| CHEMBL214066 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212213 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL212982 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL209440 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL386055 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL209488 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL214371 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL380034 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL214066 | — | IC50 | = | 24000.0 | nM | 4.62 |