Assay Detail
Binding
CHEMBL869795
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Inhibition of MMP2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of butynyloxyphenyl beta-sulfone piperidine hydroxamates as TACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.10 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210133 | — | — | 1 | 8.51 |
| CHEMBL211726 | — | — | 1 | 7.82 |
| CHEMBL212411 | — | — | 1 | 7.80 |
| CHEMBL211770 | — | — | 1 | 7.72 |
| CHEMBL377272 | — | — | 1 | 7.62 |
| CHEMBL379763 | — | — | 1 | 7.36 |
| CHEMBL377317 | — | — | 1 | 7.34 |
| CHEMBL211487 | — | — | 1 | 7.31 |
| CHEMBL211274 | — | — | 1 | 7.27 |
| CHEMBL212481 | — | — | 1 | 7.21 |
| CHEMBL387079 | — | — | 1 | 7.11 |
| CHEMBL377862 | — | — | 1 | 6.96 |
| CHEMBL208841 | — | — | 1 | 6.95 |
| CHEMBL209490 | — | — | 1 | 6.60 |
| CHEMBL425783 | — | — | 1 | 6.52 |
| CHEMBL380049 | — | — | 1 | 6.47 |
| CHEMBL379287 | — | — | 1 | 6.46 |
| CHEMBL209970 | — | — | 1 | 6.45 |
| CHEMBL210084 | — | — | 1 | 6.29 |
| CHEMBL212205 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210133 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL211726 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL212411 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL211770 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL377272 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL379763 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL377317 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL211487 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL211274 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL212481 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL387079 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL377862 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL208841 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL209490 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL425783 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL380049 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL379287 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL209970 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL210084 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL212205 | — | IC50 | = | 553.0 | nM | 6.26 |