Assay Detail
Functional
CHEMBL869823
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Cytotoxicity against human MiaPaca2 cell line
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 13-amino costunolide derivatives as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.77 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212687 | — | — | 1 | 5.28 |
| CHEMBL209170 | — | — | 1 | 5.27 |
| CHEMBL211721 | — | — | 1 | 5.10 |
| CHEMBL379127 | — | — | 1 | 5.01 |
| CHEMBL374848 | — | — | 1 | 4.96 |
| CHEMBL373564 | — | — | 1 | 4.89 |
| CHEMBL377003 | — | — | 1 | 4.77 |
| CHEMBL86416 | COSTUNOLIDE | — | 1 | 4.75 |
| CHEMBL211817 | — | — | 1 | 4.64 |
| CHEMBL213622 | — | — | 1 | 4.63 |
| CHEMBL211718 | — | — | 1 | 4.47 |
| CHEMBL214292 | — | — | 1 | 4.29 |
| CHEMBL406137 | — | — | 1 | 4.00 |
| CHEMBL211682 | — | — | 1 | - |
| CHEMBL425070 | — | — | 1 | - |
| CHEMBL438057 | — | — | 1 | - |
| CHEMBL209999 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212687 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL209170 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL211721 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL379127 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL374848 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL373564 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL377003 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL86416 | COSTUNOLIDE | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL211817 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL213622 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL211718 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL214292 | — | IC50 | = | 51700.0 | nM | 4.29 |
| CHEMBL406137 | — | IC50 | = | 98900.0 | nM | 4.00 |
| CHEMBL211682 | — | IC50 | - | — | - | |
| CHEMBL425070 | — | IC50 | - | — | - | |
| CHEMBL438057 | — | IC50 | - | — | - | |
| CHEMBL209999 | — | IC50 | - | — | - |