Assay Detail
Binding
CHEMBL869847
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Inhibition of KDR at 1 mM ATP by HTRF assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 6.81 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213910 | — | — | 1 | 7.96 |
| CHEMBL378831 | — | — | 1 | 7.92 |
| CHEMBL384294 | — | — | 1 | 7.80 |
| CHEMBL212932 | — | — | 1 | 7.77 |
| CHEMBL215948 | — | — | 1 | 7.75 |
| CHEMBL211464 | — | — | 1 | 7.72 |
| CHEMBL378895 | — | — | 1 | 7.70 |
| CHEMBL380243 | — | — | 1 | 7.68 |
| CHEMBL214063 | — | — | 1 | 7.68 |
| CHEMBL379088 | — | — | 1 | 7.57 |
| CHEMBL212986 | — | — | 1 | 7.47 |
| CHEMBL380068 | — | — | 1 | 7.46 |
| CHEMBL378440 | — | — | 1 | 7.38 |
| CHEMBL213430 | — | — | 1 | 7.35 |
| CHEMBL214161 | — | — | 1 | 7.32 |
| CHEMBL223220 | — | — | 1 | 7.29 |
| CHEMBL213507 | — | — | 1 | 7.21 |
| CHEMBL209919 | — | — | 1 | 7.20 |
| CHEMBL380397 | — | — | 1 | 7.10 |
| CHEMBL211307 | — | — | 1 | 6.99 |
| CHEMBL2096839 | — | — | 1 | 6.98 |
| CHEMBL377400 | — | — | 1 | 6.91 |
| CHEMBL209421 | — | — | 1 | 6.91 |
| CHEMBL212084 | — | — | 1 | 6.83 |
| CHEMBL225248 | — | — | 1 | 6.80 |
| CHEMBL212985 | — | — | 1 | 6.80 |
| CHEMBL210070 | — | — | 1 | 6.79 |
| CHEMBL213270 | — | — | 1 | 6.77 |
| CHEMBL213743 | — | — | 1 | 6.75 |
| CHEMBL215563 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213910 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL378831 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL384294 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL212932 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL215948 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL211464 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL378895 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL380243 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL214063 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL379088 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL212986 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL380068 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL378440 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL213430 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL214161 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL223220 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL213507 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL209919 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL380397 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL211307 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2096839 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL377400 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL209421 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL212084 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL212985 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL225248 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL210070 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL213270 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL213743 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL215563 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL209971 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL210113 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL209922 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL212499 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL214109 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL213909 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL212762 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL415047 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL425615 | — | IC50 | = | 444.0 | nM | 6.35 |
| CHEMBL213796 | — | IC50 | = | 459.0 | nM | 6.34 |
| CHEMBL213138 | — | IC50 | = | 2777.0 | nM | 5.56 |
| CHEMBL215417 | — | IC50 | = | 2882.0 | nM | 5.54 |
| CHEMBL425262 | — | IC50 | = | 4807.0 | nM | 5.32 |
| CHEMBL212987 | — | IC50 | = | 7458.0 | nM | 5.13 |
| CHEMBL211515 | — | IC50 | = | 12285.0 | nM | 4.91 |
| CHEMBL213230 | — | IC50 | = | 22795.0 | nM | 4.64 |
| CHEMBL384939 | — | IC50 | = | 24158.0 | nM | 4.62 |
| CHEMBL211567 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL443835 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL214214 | — | IC50 | > | 50000.0 | nM | - |