Assay Detail
Binding
CHEMBL869911
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition bRaf kinase activity
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.48 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200889 | — | — | 1 | 8.22 |
| CHEMBL381250 | — | — | 1 | 8.22 |
| CHEMBL200320 | — | — | 1 | 8.10 |
| CHEMBL373011 | — | — | 1 | 8.00 |
| CHEMBL200172 | — | — | 1 | 7.92 |
| CHEMBL200863 | — | — | 1 | 7.89 |
| CHEMBL371952 | — | — | 1 | 7.89 |
| CHEMBL381447 | — | — | 1 | 7.85 |
| CHEMBL200118 | — | — | 1 | 7.48 |
| CHEMBL426476 | — | — | 1 | 7.40 |
| CHEMBL68215 | — | — | 1 | 6.47 |
| CHEMBL371694 | — | — | 1 | 6.05 |
| CHEMBL200259 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200889 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL381250 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL200320 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL373011 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL200172 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL200863 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL371952 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL381447 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL200118 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL426476 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL68215 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL371694 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL200259 | — | IC50 | = | 1585.0 | nM | 5.80 |