Assay Detail
Binding
CHEMBL869914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at bRaf kinase in fluorescent ligand displacement assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 30 | 7.92 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477989 | SB590885 | — | 1 | 9.52 |
| CHEMBL372543 | — | — | 1 | 8.89 |
| CHEMBL200172 | — | — | 1 | 8.70 |
| CHEMBL373011 | — | — | 1 | 8.62 |
| CHEMBL371952 | — | — | 1 | 8.38 |
| CHEMBL200889 | — | — | 1 | 8.32 |
| CHEMBL200783 | — | — | 1 | 8.30 |
| CHEMBL200320 | — | — | 1 | 8.28 |
| CHEMBL200258 | — | — | 1 | 8.24 |
| CHEMBL200412 | — | — | 1 | 8.22 |
| CHEMBL304624 | — | — | 1 | 8.10 |
| CHEMBL381447 | — | — | 1 | 8.00 |
| CHEMBL200637 | — | — | 1 | 7.96 |
| CHEMBL370353 | — | — | 1 | 7.85 |
| CHEMBL200164 | — | — | 1 | 7.77 |
| CHEMBL200863 | — | — | 1 | 7.68 |
| CHEMBL427196 | — | — | 1 | 7.66 |
| CHEMBL426476 | — | — | 1 | 7.62 |
| CHEMBL200942 | — | — | 1 | 7.57 |
| CHEMBL200118 | — | — | 1 | 7.41 |
| CHEMBL200431 | — | — | 1 | 7.28 |
| CHEMBL200226 | — | — | 1 | 7.15 |
| CHEMBL381421 | — | — | 1 | 7.06 |
| CHEMBL435744 | — | — | 1 | 6.88 |
| CHEMBL68215 | — | — | 1 | 6.50 |
| CHEMBL200156 | — | — | 1 | - |
| CHEMBL200782 | — | — | 1 | - |
| CHEMBL200861 | — | — | 1 | - |
| CHEMBL305023 | — | — | 1 | - |
| CHEMBL200259 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477989 | SB590885 | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL372543 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL200172 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL373011 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL371952 | — | Kd | = | 4.2 | nM | 8.38 |
| CHEMBL200889 | — | Kd | = | 4.8 | nM | 8.32 |
| CHEMBL200783 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL200320 | — | Kd | = | 5.3 | nM | 8.28 |
| CHEMBL200258 | — | Kd | = | 5.7 | nM | 8.24 |
| CHEMBL200412 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL304624 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL381447 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL200637 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL370353 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL200164 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL200863 | — | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL427196 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL426476 | — | Kd | = | 24.0 | nM | 7.62 |
| CHEMBL200942 | — | Kd | = | 27.0 | nM | 7.57 |
| CHEMBL200118 | — | Kd | = | 39.0 | nM | 7.41 |
| CHEMBL200431 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL200226 | — | Kd | = | 71.0 | nM | 7.15 |
| CHEMBL381421 | — | Kd | = | 87.0 | nM | 7.06 |
| CHEMBL435744 | — | Kd | = | 132.0 | nM | 6.88 |
| CHEMBL68215 | — | Kd | = | 316.0 | nM | 6.50 |
| CHEMBL200156 | — | Kd | > | 200.0 | nM | - |
| CHEMBL200782 | — | Kd | > | 200.0 | nM | - |
| CHEMBL200861 | — | Kd | > | 200.0 | nM | - |
| CHEMBL305023 | — | Kd | > | 196.0 | nM | - |
| CHEMBL200259 | — | Kd | > | 196.0 | nM | - |