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Assay Detail

CHEMBL869935

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of TXB2 production in Sprague-Dawley rat whole blood
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Blood
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.
McKew JC, Foley MA, Thakker P, Behnke ML, Lovering FE, Sum FW, Tam S, Wu K, Shen MW, Zhang W, Gonzalez M, Liu S, Mahadevan A, Sard H, Khor SP, Clark JD.
J Med Chem (2006) 49 : 135 -158
PubMed 16392799 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 42 5.02 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL383420 1 6.10
CHEMBL382306 1 5.70
CHEMBL201135 1 5.70
CHEMBL372790 1 5.70
CHEMBL381471 1 5.52
CHEMBL201267 1 5.52
CHEMBL380631 1 5.40
CHEMBL199669 1 5.30
CHEMBL370366 1 5.30
CHEMBL200054 1 5.22
CHEMBL198292 1 5.16
CHEMBL371226 1 5.16
CHEMBL197759 1 5.10
CHEMBL199533 1 5.10
CHEMBL199751 1 5.05
CHEMBL198592 1 5.05
CHEMBL199644 1 5.00
CHEMBL201194 1 5.00
CHEMBL29838 1 4.92
CHEMBL370113 1 4.92
CHEMBL199745 1 4.89
CHEMBL370799 1 4.89
CHEMBL199714 1 4.85
CHEMBL199979 1 4.85
CHEMBL381068 1 4.60
CHEMBL201428 1 4.60
CHEMBL200025 1 4.60
CHEMBL201647 1 4.60
CHEMBL199500 1 4.32
CHEMBL381067 1 4.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL383420 IC50 = 800.0 nM 6.10
CHEMBL382306 IC50 = 2000.0 nM 5.70
CHEMBL372790 IC50 = 2000.0 nM 5.70
CHEMBL201135 IC50 = 2000.0 nM 5.70
CHEMBL381471 IC50 = 3000.0 nM 5.52
CHEMBL201267 IC50 = 3000.0 nM 5.52
CHEMBL380631 IC50 = 4000.0 nM 5.40
CHEMBL199669 IC50 = 5000.0 nM 5.30
CHEMBL370366 IC50 = 5000.0 nM 5.30
CHEMBL200054 IC50 = 6000.0 nM 5.22
CHEMBL198292 IC50 = 7000.0 nM 5.16
CHEMBL371226 IC50 = 7000.0 nM 5.16
CHEMBL197759 IC50 = 8000.0 nM 5.10
CHEMBL199533 IC50 = 8000.0 nM 5.10
CHEMBL198592 IC50 = 9000.0 nM 5.05
CHEMBL199751 IC50 = 9000.0 nM 5.05
CHEMBL199644 IC50 = 10000.0 nM 5.00
CHEMBL201194 IC50 = 10000.0 nM 5.00
CHEMBL29838 IC50 = 12000.0 nM 4.92
CHEMBL370113 IC50 = 12000.0 nM 4.92
CHEMBL370799 IC50 = 13000.0 nM 4.89
CHEMBL199745 IC50 = 13000.0 nM 4.89
CHEMBL199714 IC50 = 14000.0 nM 4.85
CHEMBL199979 IC50 = 14000.0 nM 4.85
CHEMBL381068 IC50 = 25000.0 nM 4.60
CHEMBL201428 IC50 = 25000.0 nM 4.60
CHEMBL200025 IC50 = 25000.0 nM 4.60
CHEMBL201647 IC50 = 25000.0 nM 4.60
CHEMBL199500 IC50 = 48000.0 nM 4.32
CHEMBL381067 IC50 = 50000.0 nM 4.30
CHEMBL425029 IC50 = 50000.0 nM 4.30
CHEMBL383492 IC50 = 100000.0 nM 4.00
CHEMBL381114 IC50 > 50000.0 nM -
CHEMBL199534 IC50 > 100000.0 nM -
CHEMBL139858 IC50 > 400000.0 nM -
CHEMBL199867 IC50 > 25000.0 nM -
CHEMBL378803 IC50 > 50000.0 nM -
CHEMBL201266 IC50 - -
CHEMBL201535 IC50 > 50000.0 nM -
CHEMBL382105 IC50 > 25000.0 nM -
CHEMBL372950 IC50 > 10000.0 nM -
CHEMBL371299 IC50 < 100000.0 nM -