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Assay Detail

CHEMBL869966

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Functional
Inhibition of growth of SCLC cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SCLC
Confidence 1 — Organism
Curated By Expert

Target

SCLC (CHEMBL612541)
Type CELL-LINE

Publication

New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.
De Martino G, Edler MC, La Regina G, Coluccia A, Barbera MC, Barrow D, Nicholson RI, Chiosis G, Brancale A, Hamel E, Artico M, Silvestri R.
J Med Chem (2006) 49 : 947 -954
PubMed 16451061 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.37 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL201490 1 7.75
CHEMBL202029 1 7.08
CHEMBL381787 1 7.03
CHEMBL381933 1 6.67
CHEMBL373244 1 6.23
CHEMBL380903 1 6.23
CHEMBL382827 1 5.66
CHEMBL203353 1 5.50
CHEMBL372987 1 5.16
CHEMBL200978 1 -
CHEMBL200078 1 -
CHEMBL201898 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL201490 IC50 = 18.0 nM 7.75
CHEMBL202029 IC50 = 84.0 nM 7.08
CHEMBL381787 IC50 = 93.0 nM 7.03
CHEMBL381933 IC50 = 216.0 nM 6.67
CHEMBL373244 IC50 = 585.0 nM 6.23
CHEMBL380903 IC50 = 584.0 nM 6.23
CHEMBL382827 IC50 = 2200.0 nM 5.66
CHEMBL203353 IC50 = 3200.0 nM 5.50
CHEMBL372987 IC50 = 7000.0 nM 5.16
CHEMBL200978 IC50 > 10000.0 nM -
CHEMBL200078 IC50 > 10000.0 nM -
CHEMBL201898 IC50 > 10000.0 nM -