Assay Detail
Functional
CHEMBL870009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMC
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.56 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72511 | — | — | 1 | 7.32 |
| CHEMBL382705 | — | — | 1 | 6.50 |
| CHEMBL208181 | — | — | 1 | 6.32 |
| CHEMBL207756 | — | — | 1 | 6.08 |
| CHEMBL439330 | — | — | 1 | - |
| CHEMBL206875 | — | — | 1 | - |
| CHEMBL438964 | — | — | 1 | - |
| CHEMBL115653 | CIPEMASTAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72511 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL382705 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL208181 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL207756 | — | IC50 | = | 836.0 | nM | 6.08 |
| CHEMBL439330 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL206875 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL438964 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL115653 | CIPEMASTAT | IC50 | > | 10000.0 | nM | - |