Assay Detail
Binding
CHEMBL870058
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Displacement of [125I]I-AB-MECA from human adenosine A3 receptor Q167E mutant expressed in COS7 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.69 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382812 | — | — | 1 | 6.24 |
| CHEMBL208475 | — | — | 1 | 5.14 |
| CHEMBL377071 | — | — | 1 | - |
| CHEMBL382194 | — | — | 1 | - |
| CHEMBL378069 | — | — | 1 | - |
| CHEMBL144521 | — | — | 1 | - |
| CHEMBL207610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382812 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL208475 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL377071 | — | Ki | - | — | - | |
| CHEMBL382194 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL378069 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL144521 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL207610 | — | Ki | > | 10000.0 | nM | - |