Assay Detail
Functional
CHEMBL870067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.87 | 6.75 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382194 | — | — | 1 | 6.75 |
| CHEMBL464859 | NECA | — | 1 | 4.98 |
| CHEMBL377071 | — | — | 1 | - |
| CHEMBL2113221 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382194 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL464859 | NECA | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL377071 | — | Activity | - | — | - | |
| CHEMBL2113221 | — | Activity | - | — | - |