Assay Detail
Binding
CHEMBL870097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 5-LO
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted coumarins as potent 5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.21 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377094 | — | — | 1 | 8.05 |
| CHEMBL204365 | — | — | 1 | 7.82 |
| CHEMBL377821 | — | — | 1 | 7.58 |
| CHEMBL207057 | — | — | 1 | 7.57 |
| CHEMBL205800 | — | — | 1 | 7.57 |
| CHEMBL205189 | — | — | 1 | 7.26 |
| CHEMBL204633 | — | — | 1 | 6.76 |
| CHEMBL205222 | — | — | 1 | 6.76 |
| CHEMBL206632 | — | — | 1 | 6.75 |
| CHEMBL207109 | — | — | 1 | 6.70 |
| CHEMBL204781 | — | — | 1 | 6.52 |
| CHEMBL204890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377094 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL204365 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL377821 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL207057 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL205800 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL205189 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL204633 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL205222 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL206632 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL207109 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL204781 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL204890 | — | IC50 | - | — | - |